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Related Experiment Video

Updated: Jun 3, 2026

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
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Troponin elevations after electroconvulsive therapy: the need for caution.

Matthew W Martinez1, Keith G Rasmussen, Paul S Mueller

  • 1Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minn., USA.

The American Journal of Medicine
|March 15, 2011
PubMed
Summary
This summary is machine-generated.

Electroconvulsive therapy can cause cardiac troponin (cTn) elevations in patients with depression. These elevations, occurring before or during treatment, may warrant closer medical monitoring due to their association with adverse outcomes.

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Area of Science:

  • Cardiology
  • Psychiatry
  • Clinical Biochemistry

Background:

  • Electroconvulsive therapy (ECT) treats severe depression.
  • Troponin elevations indicate poor prognosis and can result from central nervous system insults.
  • The link between ECT and cardiac troponin elevation was previously unstudied.

Purpose of the Study:

  • To investigate the incidence and timing of cardiac troponin (cTn) elevations in patients undergoing electroconvulsive therapy (ECT).
  • To assess the clinical significance of cTn elevations in the context of ECT.

Main Methods:

  • Seventy patients undergoing ECT were enrolled.
  • Baseline and post-ECT electrocardiograms and serum samples for cardiac troponin I (cTnI) and T (cTnT) were collected.
  • cTn levels were measured, with values above the 99th percentile considered abnormal.

Main Results:

  • Elevated cTn levels were observed in 11.5% of patients.
  • Some elevations were present before ECT, while others occurred during the procedure.
  • Two patients with cTn elevations died during the follow-up period.

Conclusions:

  • Cardiac troponin elevations are a notable finding in patients receiving ECT.
  • The occurrence of elevations both before and during ECT suggests complex interactions.
  • Given the prognostic implications of cTn elevations, increased medical scrutiny for ECT patients is recommended.