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Wolf's isotopic response.

Ronni Wolf1, Danny Wolf, Eleonora Ruocco

  • 1Dermatology Unit, Kaplan Medical Center, 76100 Rechovot, Israel. wolf_r@netvision.net.il

Clinics in Dermatology
|March 15, 2011
PubMed
Summary
This summary is machine-generated.

Wolf's isotopic response is a new skin disorder appearing at the site of a previous, healed skin disease. This review clarifies its definition and distinguishes it from similar phenomena like Koebner isomorphic response.

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Area of Science:

  • Dermatology
  • Medical Eponyms

Background:

  • The term "isotopic response" was introduced by Wolf et al. in 1995.
  • It describes new skin disorders at sites of prior, healed, unrelated skin diseases.
  • The term was modified to "Wolf's isotopic response" for improved searchability.

Purpose of the Study:

  • To describe Wolf's isotopic response and present clinical examples.
  • To address definitional challenges and overlap with Koebner isomorphic response.
  • To discuss "isotopic nonresponse" and related concepts.

Main Methods:

  • Literature search yielding 176 cases of Wolf's isotopic response.
  • Analysis of clinical morphology of the phenomenon.
  • Comparison with Koebner isomorphic response and "isotopic nonresponse".

Main Results:

  • Wolf's isotopic response is a distinct dermatological phenomenon.
  • Definitional issues and overlap with Koebner isomorphic response were identified.
  • The concept of "isotopic nonresponse" was also examined.

Conclusions:

  • Wolf's isotopic response is a clinically recognized entity.
  • Clear differentiation from isomorphic responses is crucial.
  • Further research into etiology and pathogenesis is warranted, though not covered here.