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Xiaodong Pang1, Mingjun Zhang, Linxiang Zhou

  • 1State Key Laboratory of Surface Physics, Department of Physics, Fudan University, Shanghai 200433, China.

European Journal of Medicinal Chemistry
|March 15, 2011
PubMed

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Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...