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Updated: Jun 3, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
Myosin light chain kinases and phosphatase in mitosis and cytokinesis
Fumio Matsumura1, Yoshihiko Yamakita, Shigeko Yamashiro
1Department of Molecular Biology & Biochemistry, Rutgers, Piscataway, NJ 08854, USA. matsumura@biology.rutgers.edu
Abstract:
At mitosis, cells undergo drastic alterations in morphology and cytoskeletal organization including cell rounding during prophase, mitotic spindle assembly during prometaphase and metaphase, chromatid segregation in anaphase, and cytokinesis during telophase. It is well established that myosin II is a motor responsible for cytokinesis. Recent reports have indicated that myosin II is also involved in spindle assembly and karyokinesis. In this review, we summarize current understanding of the functions of myosin II in mitosis and cytokinesis of higher eukaryotes, and discuss the roles of possible upstream molecules that control myosin II in these mitotic events.
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