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Updated: Jun 3, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
[Strategies in castration-resistant prostate cancer]
T Bessede1, P Beuzeboc, F Bladou
1Service d'Urologie, Hôpital Bicêtre, 78, rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France. thomas.bessede@gmail.com
Summary
Treating castration-resistant prostate cancer involves immediate or delayed strategies. Promising new therapies like endothelin inhibitors and novel anti-androgens are under investigation in clinical trials.
Area of Science:
- Oncology
- Urology
- Pharmacology
Context:
- Castration-resistant prostate cancer (CRPC) presents complex treatment challenges.
- Therapeutic decisions for CRPC depend on clinical circumstances and disease progression.
- Advances in tumor biology are identifying novel therapeutic targets.
Purpose:
- To review current and emerging treatment strategies for castration-resistant prostate cancer.
- To highlight promising therapeutic agents and their developmental status.
Summary:
- Treatment for CRPC can be initiated promptly or deferred based on patient factors.
- Emerging treatments target specific tumor biology pathways.
- Key investigational therapies include estrogens, novel anti-androgens (e.g., abiraterone, MDV3100, RD162), and endothelin inhibitors.
Impact:
- This review provides an overview of the evolving landscape of CRPC treatment.
- It emphasizes the importance of clinical trials for accessing novel therapeutic options.
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