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Updated: Jun 3, 2026

Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols

Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols

Published on: October 18, 2016

Expression of complement components, receptors and regulators by human dendritic cells.

Ke Li¹, Henrieta Fazekasova, Naiyin Wang

¹King's College London, MRC Centre for Transplantation, NIHR Comprehensive Biomedical Research Centre, Guy's Hospital, London, UK.

Molecular Immunology

|March 15, 2011

Summary

This summary is machine-generated.

Dendritic cells (DCs) integrate innate and adaptive immunity by expressing complement system components. This convergence enhances host defense and understanding of immune-mediated diseases.

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Area of Science:

Immunology
Cell Biology

Background:

The integration of innate and adaptive immunity is crucial for effective host defense and managing aberrant immune responses.
Dendritic cells (DCs) play a central role in bridging these two arms of the immune system.

Purpose of the Study:

To investigate the convergence of complement activation and antigen presentation functions on human dendritic cells (DCs).
To characterize the expression of complement system components and their regulators on various human DC subsets.

Main Methods:

Analysis of complement component and receptor expression on multiple human DC subsets (monocyte-derived, dermal, Langerhans, myeloid, plasmacytoid).
Detection of complement activation peptides (C3a, C5a) and fragments (C3b, iC3b, C3d) via specific receptors (C3aR, C5aR, CR3, CR4, CRIg).
Identification of membrane-bound complement regulatory proteins (CD46, CD55, CD59) on the DC surface.

Main Results:

Human DCs express numerous components of the classical, alternative, and terminal complement pathways.
DCs possess receptors for complement peptides (C3a, C5a) and fragments (C3b, iC3b, C3d), facilitating immune adhesion.
DCs express membrane-bound complement regulators (CD46, CD55, CD59) involved in intracellular signaling.

Conclusions:

Human dendritic cells are key sites for the integration of complement activation and antigen presentation.
The comprehensive expression of complement components and regulators on DCs highlights their critical role in host defense.
This study provides a foundational resource for understanding complement's role in human health and immune diseases.