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Published on: May 24, 2024
Longitudinal changes in macrophage migration inhibitory factor in breast milk during the first three months of
Eva Vigh1, József Bódis, János Garai
1Department of Pathophysiology and Gerontology, Medical School, University of Pécs, Pécs, Hungary.
Abstract:
The presence of macrophage migration inhibitory factor (MIF) in breast milk has been reported before, but its concentration at distinct phases of lactation has not yet been delineated. We have measured the MIF content in the aqueous phase of 63 milk samples from 21 mothers at postpartum days 5, 12 and 84 by enzyme-linked immunosorbent assay. MIF declined consistently from 44.5±40.3 ng/ml at day 5 to 20.3±12.9 ng/ml at day 84, but no similar trend was found in the ng/mg protein values. MIF may play a relevant role in the complex immunological interface between the mother and her infant.
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