Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics.

Nature communications·2022

Same author

Corroborating evidence refutes batch effect as explanation for fetal bacteria.

Microbiome·2021

Same author

Viable bacterial colonization is highly limited in the human intestine in utero.

Nature medicine·2020

Same author

Acute West Nile Virus Meningoencephalitis Diagnosed Via Metagenomic Deep Sequencing of Cerebrospinal Fluid in a Renal Transplant Patient.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016

Same author

Depletion of Abundant Sequences by Hybridization (DASH): using Cas9 to remove unwanted high-abundance species in sequencing libraries and molecular counting applications.

Genome biology·2016

Same author

Genetic variation in the vitamin d pathway in relation to risk of prostate cancer--results from the breast and prostate cancer cohort consortium.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2013

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Advanced prostate cancer.

S W Waxman¹, E D Crawford

¹Oncology Fellow, Division of Urology, University of Colorado Health Sciences Center, Denver, Colorado.

Surgical Technology International

|March 15, 2011

Summary

This summary is machine-generated.

Advanced prostate cancer definition is evolving. It now includes patients with locally advanced or metastatic disease, rising PSA, or high Gleason grade, indicating significant progression risk.

More Related Videos

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

Related Experiment Videos

Last Updated: Jun 3, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

Area of Science:

Oncology
Urology

Background:

Prostate cancer is a leading cause of cancer death in US men.
Traditionally, advanced prostate cancer meant bony metastases, but definitions are changing.
Over 50% of newly diagnosed patients present with locally advanced or metastatic disease (T3, N+, or M+).

Purpose of the Study:

To redefine the concept of advanced prostate cancer based on current diagnostic and management practices.
To identify patient groups at significant risk of progression and death.

Main Methods:

Review of traditional definitions of advanced prostate cancer.
Inclusion of new criteria such as rising prostate-specific antigen (PSA) and high Gleason grade.

Main Results:

68% of patients with advanced prostate cancer respond to androgen withdrawal therapies.
Median survival for metastatic disease is 1.8 years.
Limited response to chemotherapy after hormonal therapy relapse.

Conclusions:

The definition of advanced prostate cancer should encompass not only metastatic disease (Stage D-2) but also locally advanced disease (Stage C, T-3), nodal involvement (Stage D-1, N+), rising PSA post-treatment, and high Gleason scores (9-10).
These broader criteria identify patients at high risk for prostate cancer progression and mortality.