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Solution-phase synthesis of alpha-human atrial natriuretic peptide (alpha-hANP)
M Yoshida1, M Shimokura, Y Fujiwara
1Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan.
Chemical & Pharmaceutical Bulletin
|February 1, 1990
Abstract:
Alpha-human atrial natriuretic peptide (alpha-hANP) was synthesized by assembling six peptide fragments in solution followed by deprotection with HF and subsequent air-oxidation. The trimethylbenzyl group was employed as an S-protecting group of cysteine. The HF-dimethylselenide-m-cresol system was employed as a final deprotecting reagent and, at the same time, as a reducing reagent of Met(O). Synthetic alpha-hANP elicited potent diuretic and natriuretic activity in rats.