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Updated: Jun 3, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

[Role of chorioamnionitis in the development of sepsis during labor]

A P Milovanov, A É Matsionis, G L Reznikova

    Arkhiv Patologii
    |March 16, 2011
    PubMed

    The authors emphasize the importance of pyoseptic diseases of the reproductive system, which are a major cause of maternal mortality. Clinical and morphological criteria have been elaborated to diagnose a special form of obstetric sepsis during labor. The inflammatory infiltrate was investigated by immunohistochemical studies using monoclonal antibodies and tumor necrosis factor. Lesions of the fetal integument and placenta have been found to be an initiating factor. The fetal integuments with signs of chorioamnionitis serve as the entry of pathogens during the septic process, promoted the development and course of septicemia during labor and complications, such as disseminated intravascular coagulation and infectious-toxic shock.

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