Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
Streptococcal Pharyngitis01:27

Streptococcal Pharyngitis

Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Forecasting Fetal Buprenorphine Exposure through Maternal-Fetal Physiologically Based Pharmacokinetic Modeling.

Pharmaceutics·2024
Same author

Innovations in Evaluating Statin Benefit and Efficacy in <i>Staphylococcus aureus</i> Intracellular Infection Management.

International journal of molecular sciences·2022
Same author

Buprenorphine pharmacotherapy for the management of neonatal abstinence syndrome in methadone-exposed neonates.

Paediatric & neonatal pain·2022
Same author

Pleiotropic Effects of Statins: New Therapeutic Approaches to Chronic, Recurrent Infection by <i>Staphylococcus aureus</i>.

Pharmaceutics·2021
Same author

A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome.

Pharmacology & therapeutics·2021
Same author

Utility of Repeat Testing for Congenital Hypothyroidism in Infants with Very Low Birth Weight.

The Journal of pediatrics·2021

Related Experiment Video

Updated: Jun 3, 2026

Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds
06:36

Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds

Published on: September 8, 2021

Simvastatin is protective during Staphylococcus aureus pneumonia.

Susan A McDowell1, Yan Ma, Ryosuke Kusano

  • 1Department of Biology, Ball State University, Muncie, IN, USA.

Current Pharmaceutical Biotechnology
|March 16, 2011
PubMed
Summary

Statins like simvastatin enhance bacterial clearance and reduce inflammation and coagulation in Staphylococcus aureus infections. This suggests statins may be beneficial adjuncts for treating sepsis and preventing severe outcomes.

More Related Videos

Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung
09:26

Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung

Published on: January 22, 2021

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
09:15

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Published on: February 28, 2019

Related Experiment Videos

Last Updated: Jun 3, 2026

Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds
06:36

Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds

Published on: September 8, 2021

Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung
09:26

Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung

Published on: January 22, 2021

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
09:15

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Published on: February 28, 2019

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Immunology

Background:

  • Epidemiologic studies indicate statins may reduce sepsis incidence and severity.
  • Statins are cholesterol-lowering drugs inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase.
  • The protective mechanism of statins in sepsis remains incompletely understood.

Purpose of the Study:

  • To investigate the protective mechanism of simvastatin against Staphylococcus aureus infection.
  • To test the hypothesis that simvastatin protects mice from S. aureus-induced sepsis.

Main Methods:

  • Mice were pretreated with simvastatin or buffer for two weeks.
  • Mice were challenged with S. aureus via intratracheal or intravenous routes.
  • Bacterial clearance, dissemination, lethality, inflammatory response, and coagulation factors were assessed.

Main Results:

  • Simvastatin pretreatment significantly enhanced bacterial killing (4-fold) and reduced systemic dissemination.
  • Simvastatin treatment decreased lethality (hazard ratio 8.8) and abrogated systemic inflammatory response.
  • Elevated serum protein C and reduced bronchoalveolar lavage tissue factor were observed in simvastatin-treated mice.

Conclusions:

  • Extended simvastatin treatment confers protection against S. aureus infection via enhanced bacterial clearance, anti-inflammatory, and anti-coagulant effects.
  • These findings provide mechanistic insights into statin-mediated protection in acute infections.
  • Statins show potential as adjuncts in sepsis treatment, particularly in patients with coagulopathy.