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Is the weighted z-test the best method for combining probabilities from independent tests?
1Biostatistics/Epidemiology/Research Design (BERD) Core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Zhongxue.Chen@uth.tmc.edu
Abstract:
Through simulation, Whitlock showed that when all the alternatives have the same effect size, the weighted z-test is superior to both unweighted z-test and Fisher's method when combining P-values from independent studies. In this paper, we show that under the same situation, the generalized Fisher method due to Lancaster outperforms the weighted z-test.
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