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Updated: Jun 3, 2026

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Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
Published on: January 7, 2019
Profaning the ultimate sanctuary: HIV latency in hematopoietic stem cells
Didier Trono1, Flavia Marzetta1
1School of Life Sciences and Frontiers in Genetics Program, École Polytechnique FÉdÉrale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Cell Host & Microbe
|March 16, 2011
Abstract:
The early establishment of a reservoir of latently infected T cells is a sobering obstacle to HIV eradication, in spite of the efficacy of current antiretroviral therapies. That latent proviruses might also hide in multipotent hematopoietic stem cells suggests an even more formidable challenge and potentially has therapeutic implications.

