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Updated: Jun 3, 2026
08:58
Fluorimetric Techniques for the Assessment of Sperm Membranes
Published on: November 28, 2018
Guaifenesin and increased sperm motility: a preliminary case report
Gary Means1, Cristóbal S Berry-Cabán, Kurt Hammermeuller
1Department of Family Medicine, Womack Army Medical Center, Fort Bragg, NC, USA.
International Journal of General Medicine
|March 16, 2011
Summary
Guaifenesin, an expectorant, may improve sperm motility and count in men with infertility. This case report details a patient who experienced significant improvements after taking guaifenesin for two months.
Area of Science:
- Reproductive Medicine
- Male Infertility
- Spermatozoa Physiology
Background:
- Infertility affects numerous couples worldwide, with male factors contributing significantly.
- Sperm motility is a critical determinant of male fertility.
- Current literature lacks extensive data on pharmacological interventions to enhance sperm motility.
Observation:
- A 32-year-old male presented with a 18-month history of infertility.
- Initial semen analysis revealed low sperm count and motility.
- The patient was treated with guaifenesin 600 mg extended-release tablets twice daily.
Findings:
- Following two months of guaifenesin therapy, repeat semen analysis showed marked improvement in both total sperm count and motility.
- This represents a potential novel use for guaifenesin in male reproductive health.
Implications:
- While the evidence is anecdotal, this case suggests guaifenesin may be beneficial for improving sperm parameters.
- Further clinical studies are warranted to investigate the efficacy and mechanism of action of guaifenesin in male infertility.
- This could lead to new therapeutic strategies for men with subnormal sperm counts and motility.
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