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Muscle Recovery and Fatigue01:24

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Creatine as an antioxidant.

Piero Sestili1, C Martinelli, E Colombo

  • 1Dipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Via Saffi 2, Urbino, Italy. piero.sestili@uniurb.it

Amino Acids
|March 16, 2011
PubMed
Summary
This summary is machine-generated.

Creatine monohydrate (Cr) shows benefits beyond athletic performance, impacting degenerative diseases. Its antioxidant activity offers cytoprotective effects, suggesting broader therapeutic potential.

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Pharmacology

Background:

  • Creatine monohydrate (Cr) is a widely used sports supplement.
  • Emerging research highlights Cr's potential in managing human degenerative diseases.
  • Its therapeutic effects extend beyond the known ergogenic role of the Cr/CrP system.

Purpose of the Study:

  • To explore the non-energy-related mechanisms of creatine monohydrate.
  • To investigate the cytoprotective effects of Cr beyond its ergogenic function.
  • To elucidate the role of Cr's antioxidant activity in cellular protection.

Main Methods:

  • Review of existing research articles on creatine monohydrate.
  • Analysis of studies investigating cellular targets of Cr.
  • Examination of evidence for Cr's antioxidant properties.

Main Results:

  • Creatine monohydrate exerts multiple non-energy-related effects on cellular targets.
  • Cr demonstrates significant antioxidant activity.
  • This antioxidant function contributes to the cytoprotective paradigm of Cr.

Conclusions:

  • Creatine monohydrate's benefits in degenerative diseases are partly due to its antioxidant properties.
  • Cr's antioxidant activity is a key mechanism supporting its cytoprotective role.
  • Further research into Cr's non-ergogenic effects may reveal new therapeutic applications.