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Updated: Jun 3, 2026

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Published on: February 27, 2026

Lung cancer.

Alan J Neville¹, Mridula Sara Kuruvilla

¹McMaster University, Hamilton, Ontario, Canada.

BMJ Clinical Evidence

|March 17, 2011

Summary

This summary is machine-generated.

This systematic review summarizes lung cancer treatments, including chemotherapy and radiotherapy for small cell and non-small cell lung cancer. Evidence on effectiveness and safety of various interventions is presented.

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Last Updated: Jun 3, 2026

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Published on: February 27, 2026

Area of Science:

Oncology
Pulmonology
Evidence-Based Medicine

Background:

Lung cancer is a leading cause of cancer mortality, with smoking responsible for 80-90% of cases.
Small cell lung cancer (SCLC) constitutes 20% of cases and is typically managed with chemotherapy.
Adenocarcinoma, the primary non-small cell lung cancer (NSCLC) subtype, is initially treated with surgery.

Purpose of the Study:

To systematically review and synthesize evidence on the effects of treatments for resectable and unresectable non-small cell lung cancer.
To evaluate the effects of treatments for small cell lung cancer.
To assess the effectiveness and safety of various lung cancer interventions.

Main Methods:

Conducted a systematic review of 96 systematic reviews and randomized controlled trials (RCTs).
Searched major databases (Medline, Embase, Cochrane Library) up to October 2009.
Included harms alerts from regulatory agencies (FDA, MHRA) and performed GRADE evaluations for evidence quality.

Main Results:

Identified 96 relevant systematic reviews and RCTs for analysis.
Evaluated the quality of evidence for numerous interventions using the GRADE system.
Synthesized findings on the effectiveness and safety of diverse lung cancer therapies.

Conclusions:

Presents information on the effectiveness and safety of chemotherapy (preoperative, postoperative, dose intensification).
Summarizes evidence for various radiotherapy techniques, including CHART and non-CHART hyperfractionated radiotherapy.
Details findings on first-line and second-line chemotherapy, molecular-targeted therapies (gefitinib, erlotinib), and prophylactic cranial irradiation.