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Related Experiment Video

Updated: Jun 3, 2026

Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

Published on: September 11, 2013

Retinal detachment.

Scott Fraser¹, David Steel

¹Sunderland Eye Infirmary, Sunderland, UK.

BMJ Clinical Evidence

|March 17, 2011

Summary

This summary is machine-generated.

This systematic review examines interventions for rhegmatogenous retinal detachment (RRD), a common condition where retinal breaks cause separation. It evaluates treatments to prevent progression and manage complications like proliferative vitreoretinopathy.

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Last Updated: Jun 3, 2026

Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

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Efficient and Consistent Generation of Retinal Pigment Epithelium/Choroid Flatmounts from Human Eyes for Histological Analysis

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Intraoperative Visualization of Subretinal Injection and Retinal Detachment in Rats

Intraoperative Visualization of Subretinal Injection and Retinal Detachment in Rats

Published on: March 7, 2025

Area of Science:

Ophthalmology
Retinal Surgery
Evidence-Based Medicine

Background:

Rhegmatogenous retinal detachment (RRD) is the most common type of retinal detachment, affecting approximately 1 in 10,000 individuals annually.
RRD occurs when a retinal break allows vitreous fluid to enter the subretinal space, leading to retinal separation.

Purpose of the Study:

To systematically review the effects of interventions for preventing RRD progression from retinal breaks or lattice degeneration.
To assess the efficacy and safety of various surgical interventions for RRD.
To evaluate treatments for proliferative vitreoretinopathy, a complication of RRD.

Main Methods:

Conducted a systematic review of scientific literature up to June 2010.
Searched major databases including Medline, Embase, and The Cochrane Library.
Included harms alerts from regulatory agencies like the FDA and MHRA.

Main Results:

Identified 21 systematic reviews, RCTs, and observational studies meeting inclusion criteria.
Performed a GRADE evaluation to assess the quality of evidence for different interventions.

Conclusions:

The review presents data on the effectiveness and safety of numerous interventions.
Interventions evaluated include corticosteroids, laser photocoagulation, pneumatic retinopexy, scleral buckling, gas/silicone oil tamponade, and vitrectomy.