Related Experiment Video
Updated: Jun 3, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Evidence of follicular T-cell implication in a case of IgG4-related systemic disease with interstitial nephritis
Mohamad Zaidan1, Pascale Cervera-Pierot, Sophie de Seigneux
1Service de Néphrologie et Dialyses, AP-HP, Hôpital Tenon, Paris, France.
Abstract:
IgG4-related systemic disease is a protean disorder that covers a wide variety of lesions. We report on a patient with tubulointerstitial nephritis, lymphadenopathies, sialadenitis and retroperitoneal fibrosis. The salivary gland and kidney interstitium were infiltrated with B lymphocytes and T lymphocytes and IgG3(+) and IgG4(+) plasma cells. The overexpression of IgG1 and IgG3, in addition to IgG4, the unusual abundance of interfollicular plasma cells and CD4(+) T cells in germinal centres of lymph nodes, and the dramatic response to rituximab point to possible roles of follicular helper T cells in enhancing a skewed B-cell terminal maturation and of CD20(+) B cells in disease progression.
Related Concept Videos
Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Nephrotic Syndrome I : Introduction
Inflammatory Bowel Disease III: Crohn's Disease
Hypersensitivity Reactions: Immune-Complex Reactions
Nephrotic Syndrome II : Assessment and Medical Management

