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Related Experiment Video

Updated: Jun 3, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Basal thyroid functions in first episode depressive illness : a controlled study.

V K Chopra1, D Ram

  • 1VINOD KUMAR CHOPRA, DPM, MD (Psychiatry), Senior Resident, Central Institute of Psychiatry, Kanke, Ranchi - 834 006.

Indian Journal of Psychiatry
|March 17, 2011
PubMed
Summary
This summary is machine-generated.

Depressive patients show subtle thyroid function abnormalities, with higher thyroxine levels and comparable thyroid-stimulating hormone (TSH) in those with psychotic features. This suggests a link between thyroid function and depression subtypes.

Keywords:
First-episodedepressive illnessthyroid stimulating hormone (TSH)total thyroxine (T3)total triiodothyronine (T3)

Related Experiment Videos

Last Updated: Jun 3, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Area of Science:

  • Neuroendocrinology
  • Psychiatry
  • Clinical Medicine

Background:

  • Thyroid dysfunction is linked to mood disorders.
  • Subtle thyroid function abnormalities may be present in depression.

Purpose of the Study:

  • To compare basal thyroid functions in drug-naive, first-episode depressive patients versus healthy controls.
  • To investigate thyroid function differences across depression subtypes, particularly those with psychotic features.

Main Methods:

  • Compared thyroid function tests (Total T4, Total T3, TSH) in 33 drug-naive depressive patients and 31 healthy controls.
  • Analyzed differences based on depression subtypes, including psychotic features.

Main Results:

  • Depressive patients had significantly higher mean total thyroxine (T4) levels compared to controls.
  • Total triiodothyronine (T3) was lower in depressives, but not significantly.
  • Thyroid-stimulating hormone (TSH) levels were comparable between groups.
  • Patients with psychotic depression exhibited significantly higher TSH levels than those without psychotic features.

Conclusions:

  • Thyroid function, specifically thyroxine levels, may be subtly altered in first-episode depression.
  • Elevated TSH in psychotic depression warrants further investigation into the neuroendocrine mechanisms.