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Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

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Wilson'S disease presenting with obsessive-compulsive disorder.

H S Duggal¹, H S Nizamie

¹HARPREET S. DUGGAL, DPM., Resident, Central Institute of Psychiatry, Ranchi- 834 006.

Indian Journal of Psychiatry

|March 17, 2011

Summary

Psychiatrists should be aware of Wilson's disease, a copper metabolism disorder, as it often presents with psychiatric symptoms. Early diagnosis is crucial to avoid misdiagnosis as primary psychiatric conditions.

Keywords:

Wilson's disease basal ganglia obsessive-compulsive disorder

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Area of Science:

Neurology
Psychiatry
Genetics

Background:

Wilson's disease is a genetic disorder affecting copper metabolism.
Psychiatric symptoms are common in Wilson's disease, often leading to initial misdiagnosis.
Obsessive-compulsive symptoms are a rare but documented manifestation.

Purpose of the Study:

To highlight the importance of recognizing Wilson's disease in psychiatric patients.
To describe a rare case of Wilson's disease presenting with obsessive-compulsive symptoms.
To discuss the neurobiological underpinnings of obsessive-compulsive disorder in Wilson's disease.

Main Methods:

Literature review of Wilson's disease and psychiatric presentations.
Case report detailing a patient with Wilson's disease and obsessive-compulsive symptoms.
Discussion of basal ganglia involvement in obsessive-compulsive disorder.

Main Results:

Approximately 20% of Wilson's disease cases are initially seen by psychiatrists.
Misdiagnosis as primary psychiatric illness occurs in reported cases.
Obsessive-compulsive symptoms represent a rare association with Wilson's disease.

Conclusions:

Psychiatrists require thorough knowledge of Wilson's disease for accurate initial diagnosis.
Recognition of Wilson's disease can prevent prolonged misdiagnosis and inappropriate treatment.
The basal ganglia may play a significant role in the development of obsessive-compulsive symptoms in Wilson's disease.