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Related Experiment Video

Updated: Jun 3, 2026

One-Step Approach to Fabricating Polydimethylsiloxane Microfluidic Channels of Different Geometric Sections by Sequential Wet Etching Processes

One-Step Approach to Fabricating Polydimethylsiloxane Microfluidic Channels of Different Geometric Sections by Sequential Wet Etching Processes

Published on: September 13, 2018

Multiple flow profiles for two-phase flow in single microfluidic channels through site-selective channel coating.

Hella Logtenberg¹, Maria J Lopez-Martinez, Ben L Feringa

¹Center for Systems Chemistry, Stratingh Institute for Chemistry, Faculty of Mathematics and Natural Sciences, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.

|March 17, 2011

Summary

Spatially selective surface modification of poly(dimethylsiloxane) (PDMS) microfluidic channels enables control over two-phase flow systems. Conditioning PDMS with 1-octanol is crucial for stable side-by-side flows.

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Area of Science:

Microfluidics
Surface Chemistry
Fluid Dynamics

Background:

Controlling multiphase flow in microfluidic devices is essential for various applications.
Poly(dimethylsiloxane) (PDMS) is a common material for microfluidic devices, but its surface properties can be challenging to modify selectively.
Achieving stable and distinct flow regimes within a single microchannel remains a significant hurdle.

Purpose of the Study:

To demonstrate a novel method for controlling two-phase flow systems in PDMS microfluidic devices.
To achieve spatially selective surface modification within microchannels.
To enable simultaneous, stable, side-by-side and slug flow regimes in a single channel.

Main Methods:

Utilizing laminar flow patterning of ethanol:water solutions with different polymers for selective surface modification.
Employing air pockets during the modification process to control the extent of surface alteration.
Investigating the critical role of 1-octanol pre-conditioning for stable flow behavior.

Main Results:

Successfully demonstrated spatially selective surface modification of PDMS microfluidic channels.
Achieved control over the length of modified channel sections using air pockets.
Enabled simultaneous slug flow and side-by-side flow of water:1-octanol without additional structures.
Identified 1-octanol pre-conditioning as a critical step for stable side-by-side flow.

Conclusions:

Spatially selective surface modification offers a powerful approach to control multiphase flow in PDMS microfluidic systems.
The presented method allows for the generation of complex flow patterns within a single microchannel.
Surface conditioning is a key factor in ensuring the stability and reproducibility of desired flow regimes.