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Updated: Jun 3, 2026
08:07
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Osteoblastic osteosarcoma in monostotic Paget's disease.
Teresa Calabrò1, Andreas F Mavrogenis, Pietro Ruggieri
1Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Bologna, Italy.
Musculoskeletal Surgery
|March 17, 2011
Summary
Paget
Area of Science:
- Orthopedics and Oncology
Background:
- Paget's disease affects 1-2% of the population, characterized by abnormal bone remodeling.
- Sarcomatous degeneration is a rare complication, occurring in 0.1-0.95% of patients.
Observation:
- A 75-year-old man presented with symptoms initially misdiagnosed as rotator cuff tendinopathy.
- The patient had monostotic Paget's disease, a localized form of the disorder.
Findings:
- The case involved a secondary osteosarcoma, a rare bone cancer, developing within Paget's disease.
- Osteosarcomas are the most common sarcomas in Paget's disease, but osteoblastic variants are infrequent.
Implications:
- This case highlights the importance of considering rare complications in Paget's disease, even with initial misdiagnosis.
- Accurate diagnosis through imaging and biopsy is crucial for effective management of pagetic osteosarcomas.
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