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Updated: Jun 3, 2026
16:03
A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
New cyclitol derivative from a sponge Sarcotragus species
Yonghong Liu1, Jee H Jung, Tunhai Xu
1Key Laboratory of Marine Bio-Resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. yonghongliu@scsio.ac.cn
Natural Product Research
|March 17, 2011
Summary
Researchers discovered sarcotride D, a novel cyclitol derivative, from a marine sponge. Its structure was identified using advanced NMR and MS techniques.
Area of Science:
- Marine Natural Products Chemistry
- Organic Chemistry
- Biotechnology
Background:
- Marine sponges are a rich source of structurally diverse bioactive compounds.
- Cyclitol derivatives are known for their varied biological activities.
- Bioactivity-guided isolation is a common strategy for discovering novel natural products.
Purpose of the Study:
- To isolate and characterize new chemical entities from marine organisms.
- To investigate the potential of marine sponge metabolites.
Main Methods:
- Bioactivity-guided fractionation using the brine shrimp lethality assay.
- Structure elucidation employing Nuclear Magnetic Resonance (NMR) spectroscopy.
- Mass Spectrometry (MS) analyses for molecular formula determination.
Main Results:
- Isolation of a new cyclitol derivative, designated sarcotride D (1).
- Complete structural assignment of sarcotride D through comprehensive spectroscopic data.
- Identification of the compound from a Sarcotragus species marine sponge.
Conclusions:
- Sarcotragus species harbors novel cyclitol derivatives with potential bioactivity.
- Sarcotride D represents a new addition to the class of marine-derived cyclitols.
- The study highlights the utility of bioassay-guided isolation in natural product discovery.
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