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Frequency of ocular manifestations of chronic graft versus host disease

Muhammad Aamir Arain1, Muhammad Khizar Niazi, Muhammad Dawood Khan

  • 1Armed Forces Institute of Ophthalmology, Rawalpindi. doctorarain@yahoo.com

Journal of Ayub Medical College, Abbottabad : JAMC
|March 18, 2011
PubMed

Insights

Chronic graft versus host disease (cGVHD) significantly impacts transplant survivors, frequently causing ocular complications like dry eyes. Close ophthalmic monitoring is crucial for managing these visual health issues in cGVHD patients.

Area of Science:

  • Ophthalmology
  • Hematology
  • Transplantation Medicine

Background:

  • Increasing number of hematopoietic cell transplantation survivors leads to a rise in chronic graft versus host disease (cGVHD).
  • Ocular manifestations of cGVHD are not well-documented in certain populations.
  • This study addresses the need to explore local cGVHD ocular complications.

Purpose of the Study:

  • To determine the frequency of ocular complications in patients with cGVHD.
  • To investigate the specific types of ocular surface disorders in cGVHD patients.
  • To highlight the importance of ophthalmic surveillance in bone marrow transplant recipients.

Main Methods:

  • Evaluation of 12 diagnosed cGVHD cases between June 2008 and March 2009.
  • Detailed recording of ocular manifestations, focusing on ocular surface disorders.
  • Utilized fluorescein and rose-bengal double staining for ocular surface assessment.

Main Results:

  • High prevalence of dry eyes (75%) and meibomian gland dysfunction (58.3%) observed.
  • Other complications included acute conjunctivitis (33%), lacrimal canalicular occlusion (16.7%), and rarer conditions like cataract and corneal defects.
  • Ocular surface disorders are a significant concern in cGVHD patients.

Conclusions:

  • Dry eyes and other ocular issues are common in cGVHD.
  • Ophthalmic monitoring is essential for early detection and management of visual complications.
  • Findings emphasize the need for routine eye examinations in transplant survivors with cGVHD.
Abstract

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