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Updated: Jun 3, 2026

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

Calciphylaxis.

Angie T Ng¹, David H Peng

¹Department of Dermatology, Stanford University, Stanford Medicine Outpatient Center, 450 Broadway, Redwood City, CA 94063, USA.

Dermatologic Therapy

|March 18, 2011

Summary

This summary is machine-generated.

Calciphylaxis is a painful skin condition causing calcification of small vessels, leading to severe lesions and infection risk. Symptomatic treatment shows promise for managing this high-mortality disease.

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Published on: June 2, 2022

Area of Science:

Vascular biology
Dermatology
Nephrology

Background:

Calciphylaxis involves metastatic calcification of small and medium-sized vessels.
This condition leads to severe dermatologic manifestations, often on high-fat areas.
Lesions progress to painful, black eschars, increasing infection and sepsis risk.

Purpose of the Study:

To summarize the clinical presentation, diagnosis, and management of calciphylaxis.
To highlight the challenges and current therapeutic approaches for this severe condition.

Main Methods:

Diagnosis relies on clinical history and skin biopsy.
Management is interdisciplinary, focusing on prevention, wound care, pain control, and mineral balance.

Main Results:

Calciphylaxis presents with painful, necrotic skin lesions.
High risk of infection and sepsis necessitates hospitalization.
Symptomatic treatment strategies are being explored for disease control.

Conclusions:

Calciphylaxis is a critical illness with high mortality.
Interdisciplinary management and symptomatic treatment offer potential for improved outcomes.