[Methods of administration of insulin]

Since insulin was discovered advances in insulin therapy have consisted in improvements of the metabolic balance and the patient's comfort. At present, nothing but intensive insulin therapy can ensure a sufficient metabolic control. This requires multiple injections which pen injectors should make more acceptable and infusions of insulin. In the years to come, treatment will use other routes of administrations, insulin distribution will be linked to glucose levels and native insulin will be replaced by synthetic insulin analogues the properties of which will vary with chemical substitutions.