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Updated: Jun 3, 2026

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
Published on: June 19, 2019
Neuropathology of sleep disorders: a review
Jean-Jacques Hauw1, Chantal Hausser-Hauw, Umberto De Girolami
1APHP, Hôpital de Salpêtrière, Laboratoire de Neuropathologie Raymond Escourolle, UPMC Sorbonne-Universités, CRicm, Inserm UMRS 975, CNRS UMR 7225, Paris, France. jean-jacques.hauw@psl.aphp.fr
Abstract:
Sleep disorders are important manifestations of neurodegenerativediseases and sometimes are clinically evident well before the onset of other neurological manifestations. This review addresses theneuroanatomical basis and the mechanisms of sleep regulation in humans in relation to the neuropathology of entities associated with sleep disturbances in selected diseases, including Alzheimer disease, progressive supranuclear palsy, Lewy body disorders, multiple-system atrophy, and fatal familial insomnia. This includes abnormalities of circadian rhythm, insomnia, narcolepsy, rapid eye movements sleep behavior disorders, and excessive daytime sleepiness.
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