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Updated: Jun 3, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
[Which patient with chronic atrial fibrillation suits well for device closure of the left atrial appendage?]
Insights
Atrial fibrillation, a common condition in older adults, significantly increases stroke risk. Left atrial appendage closure offers a promising alternative to oral anticoagulation for stroke prevention.
Area of Science:
- Cardiology
- Neurology
- Geriatrics
Background:
- Atrial fibrillation (AF) impacts approximately 3% of individuals over 65.
- AF is linked to a substantial proportion (15-20%) of all cerebrovascular insults.
- Chronic AF patients have a 30% risk of experiencing at least one cerebrovascular accident.
Observation:
- A CHADS2 score of 3 or higher reliably predicts future cerebrovascular events in chronic AF patients.
- Oral anticoagulation is the primary treatment for preventing thromboembolic complications in AF.
Findings:
- Percutaneous left atrial appendage closure is an emerging treatment strategy.
- This closure method shows promise as an alternative for patients intolerant to oral anticoagulation.
Implications:
- Left atrial appendage closure may reduce stroke risk in specific patient populations.
- This intervention offers a viable option for elderly patients with AF who cannot tolerate oral anticoagulants.
- Further research into left atrial appendage closure is warranted to establish its long-term efficacy and safety.
Abstract:
Atrial fibrillation affects about 3% of all persons older than 65 years of age. About 30% of patients with chronic atrial fibrillation suffer from at least one cerebrovascular accident. On the other hand, atrial fibrillation is responsible for 15 - 20% of all cerebrovascular insults. A CHADS2 score of 3 points or more has been found to be a reliable predictor of future cerebrovascular events in patients with chronic atrial fibrillation. Oral anticoagulation remains the mainstay of treatment to prevent thromboembolic complications. Percutaneous closure of the left atrial appendage is a promising approach and probably a valid alternative in older patients intolerant to oral anticoagulation.
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