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Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...
Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.
Genetic Lingo01:11

Genetic Lingo

Overview
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: Jun 3, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

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Published on: May 26, 2023

Pseudo-blue lunula and beyond: a normal variant.

Yusra Siddiqui1, Rashid M Rashid

  • 1Department of Dermatology, MD Anderson Cancer Center, University of Texas Medical School, Houston, TX 77030, USA.

Skinmed
|March 19, 2011
PubMed
Summary

A newborn developed blue nail discoloration that persisted for two weeks. This benign finding resolved spontaneously without intervention, highlighting the importance of observation in similar pediatric cases.

Area of Science:

  • Pediatrics
  • Dermatology
  • Neonatology

Background:

  • A 12-hour-old newborn presented with persistent blue nail discoloration.
  • The condition was noted by parents and healthcare providers, prompting dermatological consultation.

Observation:

  • The blue discoloration was observed from the proximal to mid-nail bed.
  • It was non-blanchable and did not resolve with warming.
  • The discoloration persisted for 7 days post-birth, with complete resolution by 2 weeks.

Findings:

  • Physical examination and laboratory results (CBC, metabolic panel) were unremarkable.
  • No cardiac murmur was detected.
  • The blue nail color was the sole presenting sign.

Implications:

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  • This case highlights a benign, transient condition in newborns.
  • It underscores the importance of clinical observation when diagnostic tests are normal.
  • Distinguishing transient blue nail discoloration from significant cyanosis is crucial for appropriate management.