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Updated: Jun 3, 2026

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Published on: May 16, 2022

Multifunctional nanoparticles for dual imaging.

Z Ali¹, A Z Abbasi, F Zhang

¹Fachbereich Physik and Wissenschaftliches Zentrum für Materialwissenschaften, Philipps Universität Marburg, Marburg, Germany.

Analytical Chemistry

|March 19, 2011

Summary

This summary is machine-generated.

Colloidal nanoparticles with inorganic cores and polymer shells enable multimodal imaging. These versatile nanoparticles can be designed for fluorescence, magnetism, or radioactivity, enhancing imaging contrast.

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Area of Science:

Materials Science
Nanotechnology
Biomedical Imaging

Background:

Multimodal imaging requires labels providing contrast across various modalities.
Colloidal nanoparticles offer a promising solution for developing advanced imaging agents.

Purpose of the Study:

To explore the potential of inorganic core-polymer shell colloidal nanoparticles for multimodal imaging.
To discuss the synthesis and properties of these nanoparticles for dual-modality applications.

Main Methods:

Synthesis of colloidal nanoparticles with inorganic cores and functional polymer shells.
Tailoring core and shell properties for fluorescence, magnetism, or radioactivity.
Combining different core-shell materials to achieve dual-modality capabilities.

Main Results:

Demonstrated successful synthesis of nanoparticles with tunable properties.
Showcased the potential for creating dual-modality agents, e.g., fluorescent cores with radioactive shells.
Highlighted the versatility of these nanoparticles for various imaging needs.

Conclusions:

Inorganic core-polymer shell nanoparticles are highly adaptable for multimodal imaging.
These nanoparticles offer a platform for developing novel contrast agents with combined functionalities.
The discussed properties and perspectives indicate significant potential for advancing imaging technologies.