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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Sleep and activity in chronic kidney disease: a longitudinal study
Rajiv Agarwal1, Robert P Light
1Indiana University School of Medicine and Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA. ragarwal@iupui.edu
Summary
Patients with chronic kidney disease (CKD) experience disrupted sleep and reduced physical activity. Hemodialysis patients show more severe sleep disturbances, which may be linked to missed dialysis sessions.
Area of Science:
- Nephrology
- Sleep Medicine
- Physical Activity Research
Background:
- Sleep disturbances and restricted physical activity are common in chronic kidney disease (CKD) and long-term dialysis patients.
- Longitudinal studies assessing these impacts are limited.
Purpose of the Study:
- To compare sleep disturbances and daytime activity levels in CKD patients, hemodialysis patients, and healthy controls.
- To investigate the longitudinal relationship between kidney function, sleep, and physical activity.
Main Methods:
- Cross-sectional and longitudinal study involving 145 CKD patients, 116 hemodialysis patients, and 19 controls.
- Sleep assessed subjectively (questionnaire) and objectively (actimetry).
- Daytime activity measured via actimetry; patients followed for up to 2 years.
Main Results:
- CKD patients without dialysis showed sleep disruption independent of risk factors and estimated GFR.
- Hemodialysis patients exhibited significantly more severe sleep disruption than CKD patients.
- Reduced daytime activity (duration and intensity) observed across controls, CKD, and hemodialysis groups.
- Missing or shortening dialysis sessions correlated with increased sleep disturbance severity cross-sectionally.
Conclusions:
- Loss of kidney function is associated with reduced physical activity.
- Sleep disruption in CKD is independent of estimated GFR but more severe in hemodialysis patients.
- Interventions like optimizing dialysis duration may improve sleep in dialysis patients.
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