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Primary skeletal Ewing's sarcoma in Down syndrome
J A Bridge1, J R Neff, D A Borek
1Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City 66103.
Cancer Genetics and Cytogenetics
|July 1, 1990
Abstract:
Primary skeletal Ewing's sarcoma that occurred in two teenage patients with Down syndrome are reported. Cytogenetic analysis of one of these tumors showed the 11;22 translocation characteristic of Ewing's sarcoma as well as other complex karyotypic changes. The possible role of constitutional trisomy 21 in development of these sarcomas is discussed.