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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

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Related Experiment Video

Updated: Jun 3, 2026

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
08:12

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

Normothermic kidney preservation.

Sarah A Hosgood1, Michael L Nicholson

  • 1Department of Infection, Immunity and Inflammation, Transplant Group, University of Leicester, Leicester General Hospital, Leicester, UK.

Current Opinion in Organ Transplantation
|March 19, 2011
PubMed
Summary
This summary is machine-generated.

Normothermic preservation offers a promising alternative to hypothermic methods for preserving donor kidneys, especially from donation after cardiac death (DCD) donors, potentially improving graft quality and reducing delayed graft function.

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Last Updated: Jun 3, 2026

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
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Published on: July 15, 2015

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Published on: May 2, 2025

Area of Science:

  • Organ transplantation research
  • Renal preservation techniques
  • Transplant immunology

Background:

  • Kidneys from marginal or donation after cardiac death (DCD) donors are highly susceptible to injury during standard hypothermic preservation.
  • Alternative preservation methods are needed to improve the quality and viability of these donor kidneys for transplantation.

Purpose of the Study:

  • To review and evaluate normothermic preservation techniques as an alternative to hypothermic preservation for donor kidneys.
  • To assess the potential of normothermic preservation to improve the quality of kidneys from DCD donors.
  • To explore the use of normothermic preservation in enhancing and assessing kidney condition prior to transplantation.

Main Methods:

  • Review of existing literature on normothermic preservation techniques in organ transplantation.
  • Analysis of studies utilizing extracorporeal membrane support for DCD donor kidney retrieval.
  • Examination of experimental and translational studies on normothermic perfusion in porcine kidney models.

Main Results:

  • Extracorporeal membrane support in DCD donor kidneys showed lower rates of delayed graft function (DGF) compared to standard retrieval.
  • Normothermic perfusion, used with hypothermic techniques, demonstrated potential for improved graft outcomes.
  • Ex-vivo and in-vivo porcine models confirmed that normothermic perfusion can replenish energy levels, improve tissue perfusion, and is a feasible preservation method.

Conclusions:

  • Normothermic preservation techniques show potential for superior tissue viability retention compared to hypothermic methods.
  • These techniques may serve as valuable tools for enhancing and assessing kidney viability, particularly for DCD donor organs.
  • Normothermic preservation offers a promising strategy to improve outcomes for marginal donor kidneys.