Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Lymphoid Cells and Tissues

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

B Cell Activation and Differentiation

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Classical Hodgkin Lymphoma Today.

Mediterranean journal of hematology and infectious diseases·2026

Same author

Building an RWD Oncology Data Mart for Diffuse Large B-Cell Lymphoma: From Data Integration to Clinical Insight.

Studies in health technology and informatics·2026

Same author

Ibrutinib or non-BTK inhibitor therapy in relapsed Waldenström macroglobulinemia: a real-life multicenter Italian study.

Blood advances·2026

Same author

Clinical impact of immunoglobulin heavy chain repertoire in mantle cell lymphoma: A study from the Fondazione Italiana Linfomi (FIL) Phase III MCL0208 trial.

HemaSphere·2026

Same author

Neuronal injury biomarkers GFAP and neurofilament light chains (NfL) are associated with neurotoxicity and endothelial dysfunction in adult patients treated with antiCD19 CART cells.

Clinical and experimental medicine·2026

Same author

Health-Related Quality of Life and Symptom Burden in Patients with Diffuse Large B-Cell Lymphoma Before Treatment with Tafasitamab and Lenalidomide: An Ad Hoc Analysis of Italian Real-World Data from the PRO-MIND Study.

Diseases (Basel, Switzerland)·2025

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

EBV in Hodgkin Lymphoma.

Giuseppina Massini¹, Doerte Siemer, Stefan Hohaus

¹Istituto di Ematologia, Universita' Cattolica S. Cuore, Rome, Italy.

Mediterranean Journal of Hematology and Infectious Diseases

|March 19, 2011

Summary

Epstein-Barr virus (EBV) is linked to nearly 40% of Hodgkin lymphoma (HL) cases, influencing tumor cells and the surrounding immune environment. EBV

Area of Science:

Oncology
Virology
Immunology

Background:

Epstein-Barr virus (EBV) is implicated in up to 40% of Hodgkin lymphoma (HL) cases.
Clonal EBV genomes are present in Hodgkin Reed-Sternberg (HRS) cells, expressing viral oncogenes (LMP1, LMP2A).
EBV infection induces epigenetic modifications in both viral and host genomes, potentially altering HRS cell phenotype.

Purpose of the Study:

To explore the role of EBV in Hodgkin lymphoma pathogenesis.
To understand EBV's impact on HRS cell biology and the tumor microenvironment.
To review the clinicopathological and epidemiological associations of EBV in HL.

Main Methods:

Analysis of viral genome presence in HL tumor cells.
Investigation of viral oncogene expression (LMP1, LMP2A) in HRS cells.

More Related Videos

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Published on: November 8, 2011

Related Experiment Videos

Last Updated: Jun 3, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Published on: November 8, 2011

Review of clinicopathological and epidemiological data correlating EBV status with HL characteristics.

Main Results:

EBV's latent infection drives expression of oncogenes contributing to HRS cell phenotype.
EBV induces epigenetic changes in host genome and alters immune cell composition/activity.
EBV presence in HL is associated with specific demographics and histological subtypes, varying geographically.

Conclusions:

EBV plays a significant role in a subset of Hodgkin lymphoma, influencing tumor biology and host response.
EBV-associated HL exhibits distinct clinicopathological features and epidemiological patterns.
Circulating EBV-DNA shows potential as a biomarker for therapy monitoring and future therapeutic targeting.