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Updated: Jun 3, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
[Genomewide association study: advances, challenges and deliberation]
Xin Tu1, Li-Song Shi, Fan Wang
1Center for Human Genome Research and College of Life Science and Technology, Key Laboratory of Molecular Biophysics of Ministry of Education, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan 430074, China.
Abstract:
Genomewide association study (GWAS) is a novel strategy for discovering genetic basis of human complex disease or trait. It utilizes millions of single nucleotide polymorphisms (SNPs) , which cover the whole genome, to conduct case-control association studies. In recent years, following the newly established Human Genome Project (HGP) and International Human HapMap project, large number of human complex disease/trait associated genetic variants have been identified through GWAS method, which provides important clues for understanding the mechanisms of related disorders. Due to the complexity of these multi-factorial diseases/traits and the complication of GWAS system itself, the GWAS remains many problems. In this review, we will discuss the potential issues in the following aspects as research methods, study subjects, genetic markers and statistical analysis.
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