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Updated: Jun 3, 2026

Assays for the Degradation of Misfolded Proteins in Cells
Published on: August 28, 2016
[Histone deacetylase 6: the key regulator of misfolded proteins]
Min Su1, Xue Sun, Chun-Feng Liu
1Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Abstract:
Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that regulates many important biological processes. It deacetylates alpha-tubulin, Hsp90 and cortactin, and forms complexes with other partner proteins. When the misfolded proteins are too more to be degradated by the chaperone refolding system and the ubiquitin-proteasome system in cultured cells, misfolded proteins are specifically transported to a cytoplasmic juxtanuclear structure called aggresome by HDAC6, facilitating their clearance by autophagy. The diverse functions of HDAC6 in misfolded proteins degradation pathway suggest that it is a potential therapeutic target for the treatment of "conformational diseases".
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