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Related Concept Videos

Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
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Chromosome Replication

Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin of...
Replication in Eukaryotes01:29

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In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
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Replication in Eukaryotes02:31

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Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
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Replication in Eukaryotes02:31

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Updated: Jun 3, 2026

Imaging Replicative Domains in Ultrastructurally Preserved Chromatin by Electron Tomography
14:56

Imaging Replicative Domains in Ultrastructurally Preserved Chromatin by Electron Tomography

Published on: May 20, 2022

Defining the replication program through the chromatin landscape.

Queying Ding1, David M MacAlpine

  • 1Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

Critical Reviews in Biochemistry and Molecular Biology
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

Accurate DNA replication ensures genome stability during the cell cycle. The chromatin environment influences origin selection, impacting genetic and epigenetic inheritance.

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Published on: May 20, 2022

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Published on: January 19, 2017

Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • DNA replication is crucial for accurate chromosome duplication during the S-phase of the cell cycle.
  • Incomplete or inaccurate DNA replication can lead to severe genomic instability.
  • Replication initiates from multiple origins across chromosomes in a coordinated manner.

Purpose of the Study:

  • To review the role of the local chromatin environment in regulating DNA replication origin selection and activation.
  • To explore the reciprocal relationship between the DNA replication program and the chromatin landscape.

Main Methods:

  • This is a review article, therefore no specific experiments were conducted.
  • The review synthesizes existing molecular evidence and research findings.

Main Results:

  • Origin selection for DNA replication is a dynamic process influenced by developmental and tissue-specific cues.
  • The local chromatin environment plays a significant role in regulating origin selection and activation.
  • Evidence suggests that DNA replication influences the chromatin landscape, impacting inheritance.

Conclusions:

  • The chromatin environment is a key regulator of the DNA replication program.
  • DNA replication is critical for both genetic and epigenetic inheritance, highlighting a feedback loop between replication and chromatin structure.