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Updated: Jun 3, 2026

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
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Adenosine-dependent concealed accessory pathway.

Diana Tint1, Csaba Kun, Ildiko Beke

  • 1Institute of Cardiology, University of Debrecen, Debrecen, Hungary.

Pacing and Clinical Electrophysiology : PACE
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

Adenosine can reveal hidden accessory pathways after ablation, which usually conduct only when adenosine is administered. This finding may help reduce recurrence rates after accessory pathway ablation procedures.

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Area of Science:

  • Electrophysiology
  • Cardiology

Background:

  • Adenosine is commonly used post-radiofrequency (RF) ablation to assess retrograde accessory pathway conduction by blocking the atrioventricular node.
  • Assessing accessory pathway conduction is crucial for preventing arrhythmia recurrence after ablation.

Observation:

  • A concealed accessory pathway was observed to conduct transiently only after adenosine administration.
  • This represents the first report of an adenosine-dependent concealed accessory pathway.

Findings:

  • Adenosine administration can elicit conduction in previously undetectable accessory pathways.
  • Dormant accessory pathway conduction can be unmasked by adenosine post-RF ablation.

Implications:

  • This finding has potential clinical implications for reducing accessory pathway ablation recurrence.
  • It provides valuable insights into adenosine's ability to elicit dormant conduction, relevant to pulmonary vein isolation procedures.