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3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
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Mandibular reconstruction using an axially vascularized tissue-engineered construct.

Ahmad M Eweida1, Ayman S Nabawi, Mona K Marei

  • 1Department of Head and Neck and Endocrine Surgery, Faculty of Medicine, University of Alexandria, Egypt. dr_ae@hotmail.com.

Annals of Surgical Innovation and Research
|March 23, 2011
PubMed
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This study introduces a novel animal model for mandibular reconstruction using intrinsic axial vascularization via an Arterio-Venous (AV) loop, offering a new approach for large bone defects, especially in irradiated fields.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Oral and Maxillofacial Surgery

Background:

  • Current mandibular reconstruction methods like free flaps, bone grafts, and alloplastics have limitations.
  • Extrinsic neovascularization is insufficient for large defects, particularly in irradiated tissues.
  • A need exists for innovative regenerative strategies for complex mandibular defects.

Purpose of the Study:

  • To introduce and validate a new animal model for mandibular reconstruction.
  • To utilize intrinsic axial vascularization via an Arterio-Venous (AV) loop for tissue engineering constructs.
  • To assess the feasibility of this model for large defects in irradiated fields.

Main Methods:

  • Developed a novel animal model in adult male goats for mandibular reconstruction.

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  • Conducted cadaveric studies to identify optimal vascular axes for the AV loop.
  • Performed mechanical loading tests to evaluate defect impact on mandibular properties.
  • Executed pilot surgical studies to refine operative and postoperative procedures.

    • Main Results:

    • Identified the facial artery and vein as the optimal vascular axis for posterior mandibular defects.
    • Demonstrated that the created defect significantly altered mandibular mechanical properties (P=0.0204).
    • Observed successful feeding adaptation in goats within a week post-surgery, with no mandibular breakage over 2 months.

    Conclusions:

    • The developed model successfully demonstrates intrinsic axial vascularization for mandibular constructs using an AV loop.
    • This model is suitable for evaluating bone regeneration in large, irradiated mandibular defects.
    • This research pioneers axial vascularization of synthetic tissue engineering constructs at the defect site without tissue transfer.