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Related Concept Videos

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Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
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Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
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Postherpetic neuralgia.

Peter N Watson1

  • 1University of Toronto, Toronto, Canada.

BMJ Clinical Evidence
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

Postherpetic neuralgia affects about 10% of shingles patients. This review evaluates interventions for preventing and treating shingles-related pain, including vaccines and medications.

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Area of Science:

  • Clinical Medicine
  • Epidemiology
  • Pharmacology

Background:

  • Postherpetic neuralgia (PHN) is persistent pain following herpes zoster (shingles).
  • Incidence of PHN increases with age, affecting up to 30% of individuals over 80.
  • Approximately 2% of acute herpes zoster cases result in pain lasting over 5 years.

Purpose of the Study:

  • To systematically review interventions for preventing herpes zoster and PHN.
  • To assess interventions during acute herpes zoster to prevent PHN.
  • To evaluate treatments for established PHN after rash healing.

Main Methods:

  • A systematic review of 41 studies including systematic reviews, RCTs, and observational studies.
  • Searched major databases (Medline, Embase, Cochrane Library) up to December 2009.
  • Included harms alerts from regulatory agencies (FDA, MHRA).

Main Results:

  • The review evaluated 12 types of interventions for PHN.
  • Included corticosteroids, capsaicin, gabapentin, herpes zoster vaccine, and others.
  • GRADE evaluation assessed the quality of evidence for each intervention.

Conclusions:

  • The systematic review provides information on the effectiveness and safety of various PHN interventions.
  • Interventions assessed include vaccines, antivirals, analgesics, and antidepressants.
  • The findings aid in clinical decision-making for PHN management.