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Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice
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Published on: March 23, 2014

Leprosy.

W Cairns S Smith1, Paul Saunderson

  • 1University of Aberdeen, Aberdeen, UK.

BMJ Clinical Evidence
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates interventions for preventing and treating leprosy. It found evidence on various treatments, including multidrug therapy and vaccines, to combat this disabling disease.

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Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice
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Published on: July 15, 2011

Area of Science:

  • Infectious Diseases
  • Public Health
  • Clinical Medicine

Background:

  • Leprosy classification by the World Health Organization (WHO) is based on skin lesion count: paucibacillary (1-5) and multibacillary (>5).
  • Annually, 250,000 new leprosy cases are reported globally, with 2 million individuals experiencing leprosy-related disabilities.

Purpose of the Study:

  • To systematically review the effectiveness and safety of interventions for leprosy prevention.
  • To systematically review the effectiveness and safety of interventions for leprosy treatment.

Main Methods:

  • A systematic review was conducted, searching major databases like Medline, Embase, and The Cochrane Library up to September 2009.
  • Included studies comprised systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • Harms alerts from regulatory agencies (FDA, MHRA) were also incorporated.

Main Results:

  • Twenty systematic reviews, RCTs, or observational studies met the inclusion criteria.
  • A GRADE evaluation was performed to assess the quality of evidence for interventions.

Conclusions:

  • The review presents findings on the effectiveness and safety of various leprosy interventions.
  • Interventions assessed include chemoprophylaxis (single-dose rifampicin), vaccines (BCG, ICRC, Mycobacterium w), and multidrug treatment regimens.