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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Seborrhoeic dermatitis.

Luigi Naldi1

  • 1Centro Studi GISED, Bergamo, Italy.

BMJ Clinical Evidence
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates topical treatments for seborrhoeic dermatitis, finding various options like ketoconazole and corticosteroids effective for scalp, face, and body. Evidence quality varied, highlighting the need for further research on treatment efficacy and safety.

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Area of Science:

  • Dermatology
  • Clinical Medicine
  • Evidence-Based Medicine

Background:

  • Seborrhoeic dermatitis affects over 10% of the population, with Malassezia (Pityrosporum) ovale implicated as the causative agent.
  • Inflammatory mechanisms are not fully understood, and the condition often relapses post-treatment.
  • Topical treatments are common for managing seborrhoeic dermatitis of the scalp, face, and body.

Purpose of the Study:

  • To systematically review the effects of topical treatments for adult seborrhoeic dermatitis on the scalp, face, and body.
  • To assess the effectiveness and safety of various interventions for seborrhoeic dermatitis.

Main Methods:

  • Systematic review of 12 studies including systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • Searched major databases (Medline, Embase, Cochrane Library) up to April 2010.
  • Included harms alerts from regulatory agencies like the FDA and MHRA.

Main Results:

  • Evaluated interventions included bifonazole, emollients, ketoconazole, lithium succinate, selenium sulphide, tar shampoo, terbinafine, and topical corticosteroids.
  • GRADE evaluation was performed to assess the quality of evidence for each intervention.
  • Information on effectiveness and safety was compiled for the listed treatments.

Conclusions:

  • The review presents findings on the effectiveness and safety of multiple topical treatments for seborrhoeic dermatitis.
  • Specific interventions evaluated include antifungals (ketoconazole, bifonazole, terbinafine), corticosteroids, and other agents.
  • This systematic review provides a comprehensive overview of current evidence for managing seborrhoeic dermatitis.