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Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications

Sonali Jindal1, Shilpa Gupta, Ruchika Gupta

  • 1Department of Pathology, Hindu Rao Hospital, Delhi, India.

Hematology (Amsterdam, Netherlands)
|March 23, 2011
PubMed
Abstract

Insights

Platelet indices like mean platelet volume (MPV) and platelet distribution width (PDW) are elevated in diabetes patients. These markers, particularly PDW and MPV, can help identify diabetic complications.

Area of Science:

  • Hematology
  • Endocrinology
  • Diabetology

Background:

  • Diabetes mellitus (DM) is characterized by a prothrombotic state with increased platelet reactivity.
  • Mean platelet volume (MPV) has been linked to diabetic retinopathy.

Purpose of the Study:

  • To compare platelet indices between diabetic and non-diabetic patients.
  • To assess the utility of platelet indices in indicating diabetic complications.

Main Methods:

  • Blood samples from 75 diabetic patients (50 with complications) and 50 controls were analyzed.
  • Platelet count, MPV, platelet distribution width (PDW), and platelet-large cell ratio were measured using an automated blood cell counter.

Main Results:

  • Diabetic patients showed significantly higher MPV, PDW, and platelet-large cell ratio than controls.
  • PDW was significantly higher in diabetics with microvascular complications compared to those without.
  • Discriminant analysis using PDW and MPV accurately classified approximately 78.6% of patients with diabetic complications.

Conclusions:

  • Platelet indices, especially PDW, differ between diabetic and non-diabetic individuals.
  • PDW and MPV are valuable indicators for classifying diabetic patients with microvascular complications.

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