[Relationship between the decline of age-related renal function and central aortic pressure in healthy Uygur...

To study the relationship between the decline of age-related renal function and central arterial pressure (CAP) in Uygur healthy population.

A total of 638 healthy Uygur inhabitants from Hetian region, Xinjiang province were enrolled. They were divided into 4 groups according to their ages. Their blood pressure, serum creatinine and other indicators were detected. eGFR (estimated glomerular filtration rate) was calculated by the formula of Chinese-based MDRD (Modification of Diet in Renal Disease). CAP was measured by a pulse wave analyzer including central arterial systolic blood pressure (C-SBP), central arterial pulse pressure (C-PP), augmentation pressure (AP), augmentation index (AIX) and other components.

CAP and brachial arterial pressure tended to increase and renal function declined with age. There were gender differences in renal function. Both AP and AIX changed with age (P < 0.05). In each group, AP and AIX increased even more significantly in females (P < 0.01). The average age of subjects with a high AIX was 52 y ± 12 y. And it was elder than that of those with a low AIX (44 y ± 13 y, P = 0.000). The renal function of those with a high AIX was lower than those with a low AIX [(121 ± 25) ml.min. (1.73 m(2))(-1)] vs (131 ± 33) ml.min. (1.73 m(2))(-1), P = 0.000]. The levels of C-PP and AP were much higher in those with a high AIX (P = 0.00). The results of multivariate analysis showed that eGFR was negatively correlated with the level of AIX (P < 0.01). And it had no relationship with the brachial artery pressure (P > 0.05).

Central arterial pressure is associated with the decline of age-related renal function. Monitoring of CAP may help to screen the high-risk patients in the elderly population. This study provides rationales for new therapeutics of protecting the aging of kidneys.