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Related Experiment Video

Updated: Jun 3, 2026

Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Genetic predisposition to persistent apical periodontitis.

Jussara M Morsani1, Anita Aminoshariae, Yiping Weng Han

  • 1American Board of Endodontics, Case Western Reserve School of Dental Medicine, Cleveland, Ohio, USA.

Journal of Endodontics
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

Genetic variations in interleukin-1 beta (IL-1β) are linked to endodontic failure. Specifically, allele2 of IL-1β increases susceptibility to persistent apical periodontitis (PAP) after root canal therapy.

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Last Updated: Jun 3, 2026

Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Area of Science:

  • Endodontology
  • Immunogenetics
  • Oral Biology

Background:

  • Interleukin-1 (IL-1) is a proinflammatory cytokine crucial for host defense and bone metabolism.
  • Allele2 of IL-1β is associated with a fourfold increase in IL-1β production.
  • Persistent apical periodontitis (PAP) can occur after root canal therapy (RCT).

Purpose of the Study:

  • To investigate the role of IL-1β gene polymorphism in the pathogenesis of endodontic failure.
  • To determine if the IL-1β gene polymorphism (allele2) influences host response and predisposes to PAP.

Main Methods:

  • A case-control study design was employed.
  • 34 subjects with PAP and 61 healthy controls were recruited.
  • IL-1β gene polymorphism was analyzed using polymerase chain reaction and restriction fragment length polymorphism.

Main Results:

  • A significant difference in genotype distribution was observed between cases (70.6%) and controls (24.6%) (P < .001).
  • The polymorphic genotype associated with increased IL-1β production was more prevalent in patients with PAP.

Conclusions:

  • Specific genetic markers for elevated IL-1β production may increase susceptibility to persistent apical periodontitis.
  • IL-1β gene polymorphism is implicated in the pathogenesis of endodontic failure.