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Related Concept Videos

Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

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Related Experiment Video

Updated: Jun 3, 2026

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
07:01

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

Published on: September 11, 2020

MicroRNAs in kidney function and disease.

Sanjeev Akkina1, Bryan N Becker

  • 1College of Medicine, University of Illinois at Chicago, Chicago, Ill, USA.

Translational Research : the Journal of Laboratory and Clinical Medicine
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are small RNA molecules that control gene activity. Changes in miRNA levels are vital for kidney development and disease, offering new diagnostic and therapeutic potential.

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Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

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Related Experiment Videos

Last Updated: Jun 3, 2026

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
07:01

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

Published on: September 11, 2020

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

Area of Science:

  • Molecular Biology
  • Genetics
  • Nephrology

Background:

  • MicroRNAs (miRNAs) are short, noncoding RNA molecules regulating gene expression.
  • miRNA expression varies across tissues and is linked to disease states.
  • Kidney tissue development and pathology involve significant miRNA expression changes.

Purpose of the Study:

  • To explore the role of microRNAs in kidney development.
  • To investigate the involvement of microRNAs in kidney diseases like diabetic nephropathy, polycystic kidney disease, and lupus nephritis.
  • To highlight the potential of miRNAs as diagnostic and therapeutic targets for kidney diseases.

Main Methods:

  • Review of existing literature on miRNA function in kidney biology and disease.
  • Analysis of miRNA expression patterns in normal and pathological kidney conditions.
  • Correlation of specific miRNA alterations with disease mechanisms and manifestations.

Main Results:

  • miRNA expression is crucial for normal kidney development.
  • Aberrant miRNA expression exacerbates kidney diseases through pathways like fibrosis and proteinuria.
  • Specific miRNAs are implicated in the pathogenesis of diabetic nephropathy, polycystic kidney disease, and lupus nephritis.

Conclusions:

  • MicroRNAs play a dual role in kidney health and disease.
  • Variable miRNA expression in kidney tissue presents opportunities for novel diagnostic biomarkers.
  • Targeting miRNAs may offer new therapeutic strategies for renal pathologies.