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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

215
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
215
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

199
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
199
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

227
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
227
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

435
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
435
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

246
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
246
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

212
Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
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Related Experiment Video

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Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
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Kidney Transplantation for Erdheim-Chester Disease.

Jongwon Yoo1, Cynthia Gunsteen2, Sima Patel1

  • 1Department of Medicine, Transplant Nephrology, Loyola University Medical Center, Maywood, IL, USA.

Case Reports in Transplantation
|August 9, 2020
PubMed
Summary

Erdheim-Chester disease can cause kidney failure. Kidney transplantation offers a successful treatment option for patients achieving remission, allowing them to become dialysis-free.

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Area of Science:

  • Nephrology
  • Oncology
  • Immunology

Background:

  • Erdheim-Chester disease (ECD) is a rare systemic histiocytosis characterized by reticuloendothelial system infiltration.
  • Chronic kidney disease (CKD) in ECD typically results from retroperitoneal fibrosis causing urinary tract obstruction.
  • End-stage kidney disease (ESKD) is a severe complication requiring renal replacement therapy.

Observation:

  • This report details an ECD patient who developed ESKD.
  • The patient achieved ECD remission with vemurafenib and underwent hemodialysis.
  • Subsequently, the patient received a deceased donor kidney transplant, experiencing acute cellular rejection managed with steroids.

Findings:

  • The patient remained in complete ECD remission and became dialysis-free 16 months post-transplant.
  • Successful kidney transplantation is feasible in ECD patients with renal failure after disease remission.
  • Immunosuppression management, including conversion from mycophenolic acid to azathioprine, influenced transplant outcomes.

Implications:

  • Kidney transplantation is a viable therapeutic option for ECD patients with ESKD.
  • Achieving ECD remission is crucial for successful transplantation outcomes.
  • This case highlights the importance of multidisciplinary management for rare diseases affecting multiple organ systems.