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A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
Published on: March 24, 2017
New drugs for tuberculosis treatment
Francesca Sánchez1, José L López Colomés, Elsa Villarino
1Servei de Medicina Interna i Malalties Infeccioses, Hospital del Mar, Barcelona, Spain. psanchez@aspb.cat
Enfermedades Infecciosas Y Microbiologia Clinica
|March 23, 2011
Summary
New anti-tuberculosis drugs show promise for shorter treatment durations. Further research and development are needed, with clinical implementation likely a decade away.
Area of Science:
- Pharmacology and Microbiology
- Infectious Diseases
- Drug Discovery
Background:
- Tuberculosis (TB) treatment traditionally involves long-term therapy with isoniazid and rifampin.
- Emerging drug resistance necessitates novel therapeutic strategies.
- Advancements in anti-TB drug research offer potential for improved treatment outcomes.
Purpose of the Study:
- To review current anti-tuberculosis drug research and speculate on future treatment directions.
- To identify novel agents and combinations that could shorten TB treatment regimens.
- To explore options for multidrug-resistant and extensively-resistant TB.
Main Methods:
- Review of available data on anti-tuberculosis drug properties and ongoing research.
- Analysis of potential new drug candidates and their combinations.
- Evaluation of regimens for different TB forms, including latent and resistant infections.
Main Results:
- Higher-dose rifamycins are being evaluated in shorter regimens.
- Fluoroquinolones (moxifloxacin, gatifloxacin) and SQ109 may shorten treatment or enhance existing regimens.
- Linezolid, PA-824, and TMC207 are candidates for rifampin-free multidrug-resistant TB therapy.
- Combination of moxifloxacin and PA-824 may target latent TB.
Conclusions:
- Several new anti-tuberculosis agents and combinations show potential for shorter treatment durations.
- Development and clinical implementation of these novel regimens are projected to take at least ten years.
- Continued research is crucial for combating tuberculosis effectively.
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