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Updated: Jun 3, 2026

Supercritical Nitrogen Processing for the Purification of Reactive Porous Materials
Published on: May 15, 2015
Sodium mercaptoundecahydro-closo-dodecaborate (BSH), a boron carrier that merits more attention
Andrea Wittig1, Finn Stecher-Rasmussen, Ralf A Hilger
1Department of Radiotherapy and Radiation Oncology, University Hospital Giessen and Marburg, Philipps-University Marburg, Marburg, Germany. wittig@med.uni-marburg.de
Abstract:
Boron neutron capture therapy relies on the preferential delivery of a (10)B-compound to tumor cells. The BSH-biodistribution was investigated in nu/nu mice and human patients. The boron concentration was measured with prompt gamma ray spectroscopy. BSH accumulates to a very low extent not only in brain, but also in fat tissue, bone and muscle, which makes BSH an interesting drug not only for brain lesions but also for tumors located at the extremities. The differential uptake in different organs indicates a complex mechanism.
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