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Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
Published on: March 18, 2015
Vascular tissue engineering: towards the next generation vascular grafts
Yuji Naito1, Toshiharu Shinoka, Daniel Duncan
1Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, 10 Amistad Street, New Haven, CT 06520, USA
Advanced Drug Delivery Reviews
|March 23, 2011
Summary
Tissue engineered vascular grafts (TEVG) show promise in cardiovascular surgery but can cause stenosis. Further research into neotissue formation is needed for improved graft design.
Area of Science:
- Cardiovascular Surgery
- Regenerative Medicine
- Biomaterials Science
Background:
- Synthetic vascular grafts have limitations like thrombogenicity and infection risk.
- Tissue engineering offers a promising alternative for cardiovascular repair.
- Current limitations necessitate the development of improved vascular graft technologies.
Purpose of the Study:
- To evaluate the feasibility of tissue engineered vascular grafts (TEVG) in a clinical trial.
- To assess the safety and efficacy of TEVG created using autologous bone marrow-derived mononuclear cells (BM-MNC) seeded onto biodegradable scaffolds.
- To identify graft-related complications and inform the design of next-generation TEVG.
Main Methods:
- First clinical trial utilizing TEVG.
- Autologous bone marrow-derived mononuclear cells (BM-MNC) seeded onto biodegradable tubular scaffolds.
- Evaluation of safety profile and graft-related complications.
Main Results:
- TEVG demonstrated an excellent safety profile in the clinical trial.
- Stenosis was identified as the primary graft-related complication, occurring in approximately 16% of grafts within seven years.
- The study provides initial clinical data on the performance of TEVG.
Conclusions:
- TEVG show potential for cardiovascular surgery but require further optimization.
- Understanding the mechanisms of vascular neotissue formation is crucial for improving TEVG.
- Future research should focus on mitigating stenosis to enhance long-term graft patency and patient outcomes.
